01:694:301 Lecture Notes - Lecture 13: Conformational Change, Serca, Multiple Drug Resistance

• School: Rutgers University
• Department: Molecular Biology and Biochemistry
• Course: 01:694:301
• Professor: F Deis

Document Summary

Membrane permeability and types proteins transport: permeability is conferred to three classes of membrane proteins: pumps, carriers, and channels, pumps mediate active transport, and channels are involved with passive transport. Atp hydrolysis drives membrane transport by means of conformational change which induced by +/- of phosphoryl group to asparate site of protein: atp-binding cassette (abc) transporters. Carriers mediate transport of ions and small molecules without use of atp; 380): diffusion pass through membrane down [] gradient; Second law thermo states that molecules spontaneously move from area higher [] to lower [] Ex: lipophilic molecules such as steroid hormones can easily dissolve in lipid bilayer. Ink in water, cigarette smoke, etc: facilitated diffusion (passive) diffusion across membrane is facilitated" by channel. Passive due to its lack of energy use; energy driving movement is the ion"s own [] gradient. Channels (like enzymes) display substrate specificity" in that they facilitate transport of some ions but not others (even if related)