01:694:301 Lecture Notes - Lecture 8: Enzyme Inhibitor, Zymogen, Activation Energy
14 Nov 2018
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Chapter 8 enzymes: basic concepts and kinetics". Enzymes: highly specific catalysts: understand the general statements about enzymes on 219-229, they are very specific in both the reactions they catalyze and their choice of reactants or substrates". This specificity is due to enzyme"s precise interaction with substrate: this precision is result of 3-d structure of enzyme protein, nearly all known enzymes are proteins, the catalytic activity of many enzyme"s can depend on cofactors. Ex: atp enzyme myosin in muscle; membrane pumps and channels: they can"t move the equilibrium point. Enzymes accelerate the attainment of eq. but do not shift their positions. The equilibrium position is a function only of the free-energy difference between reactants and products: they catalyze reactions by stabilizing the transition state ( ) The transition state molecular structure in which substrate in no longer a reactant but not yet a product. Enzymes accelerate rxn by lowering activation energy.
