11:680:390 Lecture Notes - Lecture 3: Siderophore, Lyme Disease, Oxidative Phosphorylation
13 Mar 2018
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I: essential elements for all microorganisms: c (50%), h (8. %), n (1 %), o (17%), P ( . 5%), s (1. 8%: trace etals: form metal cofactors of enzymes (v, n, fe, co, ni, cu, zn, o, Iron is very important because it"s present in hemoglobin and etc needed in higher concentrations. Exception: yme disease pathogen: lack of role for iron; learned to synthesize anganese instead: growth factors: vitamins that are supplemented in the medium, transport, need to expend energy to transport ions. Bioenergetics: how microorganisms conserve energy: types of work. Synthesis of complex molecules: high energy bonds. Ovement of internal structures: atp: contains - phosphate bonds: release high energy when hydrolyzed; made primarily by oxidative phosphorylation. c-s bond between acetyl portion and b-mercaptoethylamine portion is a high energy thioester bond: some energy-yielding reactions. Organic compound + o h o + co . Organic compound + h so4 h s + co .
