01:447:380 Lecture Notes - Lecture 6: Genomic Imprinting, Gene Expression, Heredity

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26 Sep 2017
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Can"t test hypothesis in humans by setting up crosses. Difficult to see mendelian ratios in family with few progeny. We deduce mode of inheritance of a trait using pedigrees to visualize how that trait is expressed in families. Determining mode of inheritance from a pedigree: dominant vs recessive. If dominant, there is an affected individual in each generation. If complete dominance, 1 parent always shows phenotype. If sex-linked, one sex is affected more than the other. If dad is affected = won"t pass trait to sons, all daughters will be carriers. If mom is affected = all sons will be affected: x-linked dominant traits, all affected individuals have affected parent b) If dad is affected = wont pass trait to sons, all daughters will be affected. If mom is affected = 50% chance all children will be affected c: only males are affected, appear dominant, since all y-linked genes are expressed c)

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