01:146:356 Lecture 13: 03777-Systems Physiology-2016-03-01

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:356
• Professor: Gary Merrill

Document Summary

Glomerular filtration rate (gfr) and clearance (cx) are closely related. 33-8: filtered load: filtered load: load excreted provide there is no manipulation in the nephron, substance x in the ultrafiltrate and substance x in the urine. Only equal if x is not reabsorbed or secreted by the peritubular capillaries. Rate of blood flow and concentration of x in the blood flow is determined by how much of x is delivered to the filtration barrier. Rpfx x px,a = delivery, where rpfx is the renal artery plasma flow (ml/min) and px,a is the renal artery plasma concentration of x (mg/ml) In healthy adults ages 20-40, gfr=120ml/min or 180l/day. Older tha(cid:374) that, there"s a(cid:374) age depe(cid:374)de(cid:374)t redu(cid:272)tio(cid:374) of gfr. 33-8: inulin: su(cid:271)sta(cid:374)(cid:272)e that does(cid:374)"t get rea(cid:271)sor(cid:271)ed or se(cid:272)reted is inulin, the qualifications for an inulin-like substance: Must be freely filtered in glomeruli (must be of right size, have no charge, et(cid:272) (cid:895)