01:146:328 Lecture Notes - Lecture 19: Blood Film, Blood Test, Onchocerca

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:328
• Professor: Professor Fong

Document Summary

Disease: loiasis eye worm of africa. 1770: mongin first identified, unsuccessful to get worm from eye. 1778: guypt successful to remove a worm from a person"s eye. Mckenzie discovered more and sent info to patrick manson. 1912: leiper discover vector (chrysops deerfly); thus life cycle. Does not have wolbachia: life cycle: During a blood meal, an infected fly (genus chrysops, day-biting flies) introduces third-stage filarial larvae onto the skin of the human host, where they penetrate into the bite wound. The larvae develop into adults that commonly reside in subcutaneous tissue. Adults produce microfilariae measuring 250 to 300 m by. 6 to 8 m, which are sheathed and have diurnal periodicity. Microfilariae have been recovered from spinal fluids, urine, and sputum. During the day they are found in peripheral blood, but during the noncirculation phase, they are found in the lungs. The fly ingests microfilariae during a blood meal.