01:146:328 Lecture Notes - Lecture 18: Auranofin, Chlorine, Acaricide
20 May 2016
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Introducing nematodes (round worms: most abundant organisms/animals on earth. 9 billion round worms in one good fertilized soil per acre = ubiquitous. First documented by linnaeus described them as vermes: surface of nematode: cuticle allows for protection and transportation of certain nutrients, as well as different layers. Muscles and skeletal like tissues surround inner tube which is digestive tract mainly. Anterior region: circum esophogus/pharynx bulb, cloaca, nerve ring. Posterior region: rectal com ring, male or female organs, stages of life: L1: - habditiform; microfilaria forms before l1 stage (encapsulates larvae) L4: ivermectin story = major drug for roundworms. 2015 nobel prize for medicine = william c campbell, satoshi omura, and. Broad spectrum: many species: antihelminthic (worms, acaricide (ticks, insecticide (insects) 1974: 54 isolates of streptomyces sent from japan to merck and tested in mice began research into this drug. Vector: female mosquito species from the genera mansonia and aedes. Cause: lymphatic filariasis (elephantitis: 120mil infected with 20 50,000 deaths.
