01:146:328 Lecture Notes - Lecture 11: Ileum, Miltefosine, Acanthamoeba
20 May 2016
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Assigned reading for exam 2: n. fowleri genome paper by zysset burri (2014) Common pathogenic species: dispar (commensal, histolytica: 50m incidences w/40,000 deaths pathogenic, coli: (commensal, gingivalis: no cyst stage (commensal) James annesley (1828): author of book for intestinal hepatic amoebiasis. Fredrich lorsch (1873): isolated amoeba from patient"s stool in russia. Lack etc, do not produce hydrogen, and lack an electron acceptor (hydrogen) Trogocytosis: nibbled to death (takes a bite out of another cell) A process whereby lymphocytes (b, t and nk cells) conjugated to antigen-presenting cells extract surface molecules from these cells and express them on their own surface: life cycle: Cysts are typically found in formed stool, whereas trophozoites are typically found in diarrheal stool. Entamoeba histolytica occurs by ingestion of mature cysts in fecally contaminated food, water, or hands: diagnosis (looking at the size of the cyst) Microscopic identification of cysts and trophozoites in the stool is the common method for diagnosing e. histolytica.
