01:146:328 Lecture Notes - Lecture 3: Brugia Malayi, Wolbachia, Necromancy
20 May 2016
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Document Summary
Parasite evolution: caenorhabditis elegans (first organism sequenced; nematode) Parasitism: living in/on the species: virulence: level of injury brought on by the attacker onto the host. Host switching: pre-adaptation: (1956, gunther osho) Dauer stage: equivalent to infectious parasitic species (l3) Elimination: reduction to zero incidences in specific area; continuous efforts to keep incidences eliminated is needed: small amount of human genome is for protein encoding (3%) The rest are considered ncrna: who, european union, etc, ideal steps for treatment/drug. Must be able to take drugs outside of hospital. Wide dispersal assay drugs: phase for drugs: Phase 1: safety profile - how safe is the drug. Phase 2: efficacy how is good is the molecule. Phase 3: increasing test population to determine side effects: parasitologist"s dilemma. Overpopulation: is removing the parasite from the overpopulation helping. Robert malthus: negative check : ethical approaches to treating diseases in science.
