01:146:328 Lecture Notes - Lecture 5: Intestinal Villus, Sulfamethoxazole, Metronidazole
3 Apr 2016
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8 blood and tissue protozoa iii: other protist. Causative agent of babesia is babesia microti. Life cycle: vermicles (sporozoites) are introduced with the bite of a tick. The vermicle enters a erythrocyte where it develops into a trophozoite, increases in size, and undergoes binary fission, producing many merozoites. When the cell erupts the merozoites enter other erythrocytes and repeats the process, resulting in a large intraerythrocytic population in a short time. The tick acquires the infection by ingesting infected blood. The parasites are released into the intestine here it forms into a motile polymorphic isogametes. Gametic fusion forms zygotes which transform into cigar shaped ookinetes. The sporont nucleus undergoes schizogony resulting in vermicles which invades ovaries and embryos. Generations of vermicles migrate to salivary glands of newly hatched ticks. The passage of babesia from a tick to its progeny is transovarian transmission. Symptomatology and diagnosis: fatal in immunologically compromised individuals. It mimics and is often mistaken for malaria.
