01:146:328 Lecture Notes - Lecture 8: Wuchereria Bancrofti, Microfilaria, Ivermectin
18 Mar 2016
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Document Summary
Ingested with blood meal taken by suitable vector the surface) at certain times of day: example: wuchereria bancrofti maximum number of microfilaria in peripheral blood occurs between 10pm and 2am. This is because the vector is a night-feeding mosquito. During the day they stay put in blood vessels of deep tissue lungs: causes of periodicity stem from the changes in the host during sleeping. Body temperature decreases, body acidity increases, decrease of water excretion by kidneys: wuchereria bancrofti, causes lymphatic filariasis (lf, elephantiasis. Life cycle: adult worms, lymphatic ducts of human, female 8-10cm, male 40mm, microfilariae sheathed, microfilariae into lymph blood mosquido, mosquito molts to l3, which migrates to proboses, mosquito saliva ingested into host. It contains lubricants and anticoagulants that facilitate the blood meal. L3 enters the skin of dh: migrate to lymphatic ducts. Detected by using elise detecting the antigen of parasite in the blood: acute/inflammatory phase. Inflammatory responses by the host to antigen from dying adult worms.
