01:146:328 Lecture Notes - Lecture 12: Hepatocyte, Chemokine, Malaria
17 Jun 2020
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Only penetrate rbcs w. duffy antigen on its surface i) Lecture notes 1 b) i) ii) iii) iv) i) ii) iii) Relapse - recurrence of disease following initial infection regardless of another mosquito bite. If fya or fyb is present > merozoite can penetrate. If fy / no receptors > merozoite can"t penetrate i) Duffy negative individual > resistant to vivax malaria. Recovers from sickness but gets sick again many years later due to sudden increase in persistent, low level, undetected parasite population in blood. More than one ring in 1 host cell. Lecture notes 2 ii) d) Used by parasite for protein sorting and export. Gametocytes have to be taken up by mosquitoes. Following rbc invasion, trophozoites produce proteins = knobs. Adaptive mechanism that decreases clearance by the host of infected cells. Later stages ii. iii. a) b) a) b) a) b) a) b) c)
