01:146:328 Lecture Notes - Lecture 20: Leishmaniasis, Leishmania Donovani, Visceral Leishmaniasis

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:328
• Professor: A.Keating

Document Summary

Properties of an ideal antiparasitic drug: characteristics, balantidium coli, trophozoite, cyst, pathology, control, treatment. Study questions: leishmania is classified in the phylum trypanosoma and order kinetoplastida. Spherical form, no flagellum, basal body kinetoplast, surround by plasma membrane. Glycosomes anaerobic metabolism low atp. Name two types of secondary lesions and describe the pathology they cause: chiclero ulcer. Lesion on ear, pinna infected, long term infection: espandia. Increase in production of macrophages at expense of rbc. Largest protozoan parasite in humans: draw a b. coli trophozoite and label the following: peristome, cytostome, food vacuoles, cytopyge, contractile vacuoles, macronucleus, and micronucleus. Damages intestinal epithelium, flask shaped ulcer produced, hemorrhage, secondary bacterial infection, necrosis, sloughing of tissue. Sanitation: describe various characteristics of an ideal antiparasitic drug. Not harmful to host cells minimize side effects. 5 december 2018: hepatosplenomegaly, compensatory production of macrophages, death by invasion of secondary pathogens, anemia, invasion of red blood cells.