01:146:295 Lecture Notes - Lecture 3: Fischer Projection, Newman Projection, Asymmetric Carbon

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:295
• Professor: schjott

Document Summary

Chapter 3 - stereoisomerism and chirality: chirality, r-s configuration, enantiomers, diasteriomers, meso compounds, optical activity / optical purity. These isomers differ in their physical and chemical properties. e. g. cis-trans isomers (in cycloalkanes) differ in their properties due to restricted rotation about a c-c bond. (as discussed in chapter 2: chirality: it means dissymmetry. A chiral carbon is the one which is bonded to 4 different groups (also called asymmetric center-stereoisomer). If a compound has no asymmetric center, it is achiral or it may have plane of symmetry or center of symmetry. A compound with one chiral center or asymmetric center or stereocenter is chiral. A chiral molecule has a non-super imposable mirror image, a pair of enantiomers. (each molecule is chiral). Stereo chemistry can be shown either using prospective 3-d structure with wedges and dashes or by drawing newman projection (as discussed in chapter 2) or fischer projection, in which the intersection of the line represents chiral carbon.