01:146:295 Lecture Notes - Lecture 6: Markovnikov'S Rule, Electrophilic Addition, Free-Radical Addition
21 Oct 2016
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Document Summary
Chapter 6 reactions of alkene: oxymercuation reduction (markovnikov addition, hydroboration oxidation (anti-markovnikov addition, addition of halogens, electrophilic addition. Addition reaction with carbocation rearrangement. (addition of hx, h2o, roh) Addition reaction without rearrangement: stereochemistry of addition reaction, oxidation of alkenes. Addition is the most common reaction of alkenes, in which a bond of alkene changes to a bond in product: electrophilic addition reaction: Alkenes are e rich species (due to loosely held pi electrons) called nucleophiles. These e rich species (nucleophiles) attract electron deficient species (e attracting species) called electrophiles to form addition product. The electrophilic addition can follow different mechanism depending on the reagent(s) added to alkene. Page 1: addition reaction with carbocation rearrangement, addition of hx (x = cl, br, i, overall reaction, mechanism, rate = k [alkene] [hx] Rate determining step: is step i i. e. formation of carbocation, faster the formation of carbocation, i. e. lower the ea for its formation, faster the rate of product formation.
