01:119:116 Lecture Notes - Lecture 25: Bone Marrow, Extracellular Fluid, Fibrin
27 Apr 2016
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Introduction to blood: transport, maintain fluid balance, defense against pathogens; composition alter in liquid: plasma: ~55% of blood; pale yellow with many components. Salts (dissolved ions) buffer ph = 7. 4, composition of interstitial fluid. Plasma proteins: regulate fluid in plasma vs interstitial fluid. Apolipoproteins - lipid transport allow lipid soluble hormones to move in blood. Fibrinogen - clotting (serum = plasma minus fibrinogens) A. 4. gases, hormones: cellular components: produced in red bone marrow; multipoint stem cells in bone marrow can differentiate into any type of bone cells divide one daughter cell remains stem cell, other becomes specialized. Flexible biconcave discs bend pass through capillaries (in mammals, no nuclei and no mitochondria) Contain hemoglobin (iron-containing proteins) transport o2 and give blood red color. Controlled by hormone erythropoietin (epo) - produced in kidneys. Low o2 kidney produces epo stimulates production of rbcs in bone marrow. High o2 epo level reduced rbc production reduced.
