01:119:116 Lecture 12: Lecture 12 - Endocrine System
8 Mar 2017
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Lecture 12 - endocrine system: intercellular communication, introduction to hormones. Binds to target cell (any cell that has a receptor for the hormone) Has a large glycoproteins/proteins on surface of cell. Cells receive too much (cid:313) signal = receptor-down. Cells receive too little (cid:315) signal = receptor-up. Fig 45. 05: types of intercellular communication. Types of communication are classified into 5 paths. Binds with proteins on outside of cell. Enters cell and binds with internal proteins: water soluble hormones. Takes signal from outside and brings it into the cell: hormone secreted (cid:314) travels through bloodstream, binds to receptor on target, hormone does not enter cell. It binds to a membrane receptor coupled with a g protein. Bound to gdp (guanine diphosphate: when hormone binds with receptor the g protein activates (it changes shape) A gdp is phosphorylated into gtp: g protein binds to adenylyl cyclase. A membrane bound enzyme: adenylyl cyclase activates (changes shape)
