01:119:115 Lecture Notes - Lecture 26: Natural Killer Cell, Antimicrobial Peptides, Adaptive Immune System
8 Jul 2015
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Document Summary
Vertebrate innate immunity shares similarities with invertebrate immunity but also has unique properties: barrier defenses i. Include skin and mucus membranes lining digestive, respiratory, urinary, reproductive tracts. In mammals some receptors are similar to insect toll receptors: different toll-like recptor(s) (tlr) exist for molecule fragments of distinct pathogens. Figure 43. 6: phagocytic cells are white blood cells, neutrophils (engulf and destroy pathogens; attracted by signals from infected tissues. Most abundant wbc: macrophages (largest phagocytes; found around body migrating or permanently in certain types of organs, dendritic cells ( primarily in tissues in contact with environment. Interferon proteins provide innate defense against viral infections. Inflammatory response triggered by signaling molecules released after injury or infection. Figure 43. 9 polypeptide chain: binding of b cell antigen receptor to antigen causes formation of cells secreting soluble receptors, secreted proteins are antibodies (immunoglobulins/ ig, are identical to antigen receptors on b cells, except secreted (not membrane bound)
