11:067:327 Lecture Notes - Lecture 9: Neuroprotection, Ester, Adenylyl Cyclase
25 Apr 2016
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Expressed in brain, gonads, reproductive tract, major organ system. Target tissues can express more than one type of receptor for a hormone. Affinity: degree of attraction between hormone and receptor. Protein hormones bind receptors on the cell membrane. Nuclear (genomic): diffuse into the cell bind to nuclear receptors. Change shape when extracellular site is occupied. Step 1: primary messenger hormone-receptor binding. Step 2: secondary messenger adenylate cyclase activation. G-protein activates adenylate cyclase atp converted to camp. Camp protein kinase additional enzymes substrate converted to protein product. Protein products secreted proteins enhance reproductive processes. Bind to carrier proteins in plasma: steroids binding. Step 3: steroid binds to nuclear receptor. Classical genomic pathway of steroid hormone action. Er : required for fertility, expressed in gonads, brain, mammary gland, uterus. Er : not fully needed for fertility, expressed in brain, gonads, reproductive tissue. Pr-a: expressed in gonads, brain, mammary gland, uterus. Pr-b: identical to pr-a +165 aa, expressed in brain, gonads, repro tissue.
