AMY-2A Lecture Notes - Lecture 30: Schizophrenia, Endorphins, Acetyltransferase
Document Summary
Resting membrane potential of a neuron: a polarized state. Review of polarized state: na+ - k+ = atpase pump (na+) out > na+ in (k+) out < (k+) in. **leak channels- slight leak, reaches different balanced limit: k+ leak channels, na+ channels are closed at rest, cl levels (cl-) out > (cl-) in. ** chloride ions can also leak into the cell, but the electrical gradient (due to negative charge inside of the cell) balances the chemical gradient for cl- to rush in. In either case, the synthesizing enzymes are made in the cell body. Biogenic amines: catecholamines-dopamine, norepinephrine (ne), and epinephrine. Dopamine blockers- used to treat schizophrenia (thorazine and. Amphetamines- activate dopaine, serotonin, and ne receptors (speed, haloperidol) crank: indolamines- serotonin and histamine. Ne and serotonin reuptake inhibitors- used to treat depression (prozac) Serotonin also derived from tyrosine, different enzymatic pathway.
