NUR 426 Lecture Notes - Lecture 1: Overactive Bladder, Nicotinic Acetylcholine Receptor, Bronchodilator
Document Summary
Anticholinergic drugs: the sympathetic nervous system mediates the fight or flight response: sns axons react with adrenergic receptors, the parasympathetic nervous system mediates the rest and digest response: pns axons react with the cholinergic receptors. Sympathetic: fight or flight, sweaty palms, hair stands, neurotransmitter: norepinephrine, arousing, effects on body. Heart rate increases, bp increases, increased contractility. Liver releases glucose (diabetics under stress have increased glucose: adrenergic receptors. Parasympathetic: rest and digest, neurotransmitter: acetylcholine, calming, effects on body. Muscarinic (cns: m1 ans, cns, m2 ans, heart, intestinal smooth muscle, cerebellum, hindbrain. Anticholinergic drugs: prototype: atropine many uses. Dilates eyes; preop, bradyarrythmias; cholinergic poisoning: prototype: oxybutynin (ditropan) Used to treat overactive bladder: prototype: ipratropium. Anticholinergics/parasympatholytics: derived from the plant belladonna, act by competing with acetylcholine for the muscarinic acetylcholine receptor sites, do not block the nicotinic receptors. Have little or no effect at the neuromuscular junction.
