BME 20100 Lecture Notes - Lecture 11: Reactive Oxygen Species, Adrenal Medulla, Second Messenger System
27 Nov 2017
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3 basic modes (acts individually or in combination): molecule. Allosteric regulation - shape change, often induced by binding a protein or small. Covalent modification - generally reversible, often acts like on/off switch. Proximity - induced interaction of component molecules promotes transmission of signal. Secondary messengers external signal (first messenger) such as a hormone. Molecular mediators of signal transduction synthesized intracellularly in response to an. Gpcr activated ip3, which can activate a ligand-gated ion channel. A ligand-gated ion channel releases ca2+, which acts as another secondary messenger by activating ca sensing proteins like protein kinase c or calmodulin. Relatively short-lived; removal or degradation of secondary messenger terminates cellular response. Hormone made in adrenal glands (on top of kidneys) Catecholamine signaling regulated by alpha and beta adrenergic receptors which are differentially situated on tissues around body. Overall effect: mobilization of energy resources to prepare body for action. Mediates multi-organ stress response: mobilization of energy (fight or flight)
