BIOL 53700 Lecture Notes - Lecture 2: C3B, Deoxyribonuclease, Chemokine

• School: Purdue University
• Department: Biological Sciences
• Course: BIOL 53700
• Professor: Qin Deng

Document Summary

Innate: nonspecific defense that comes into play immediately after pathogen appears. Both: common effector mechanisms for destruction of pathogens. Sites of lymphocyte activation by antigens: true/false: our immune system efficiently kills all categories of microbes that attempt to colonize our bodies. What do they sense: give an example. Nods: detect bacterial products within the cytosol and activate nfkb and production of pro-inflammatory cytokines. Rig-i-like receptors: detect cytoplasmic viral rnas and induce type i interferon production. Tnfalpha: activates vascular endothelium and increases vascular permeability, leads to increase entry of igg, complement and cells to tissues and increases fluid drainage to lymph nodes, induces shock when released systemically. Il-1beta: activates vascular endothelium, activates lymphocytes, local tissue destruction, and increases access of effector cells. Liver: activate synthesis of acute-phase proteins (c-reactive protein, mannose-binding lectin) for the activation of complement opsonization. Inf-alpa/beta: induce resistance to viral replication in all cells by inducing: mx proteins, adenosine oligomers: degrade viral rna, kinase pkr: inhibit translation.