BCHM 10000 Lecture Notes - Lecture 1: Plant Cell, Chloroplast, Mitochondrion

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• What would the cytoplasm look like if you could see it?
– The cytoplasm is crowded with protein and other macromolecules
– Proteins are constantly bumping into other proteins and many of these form
semi-stable complexes
– DNA is constantly associated with proteins
– There is a limited volume through which small molecules can move
To be able to visualize biochemical reactions, it is necessary to have an understanding of scale.
Some important dimension
water (0.3-0.4 nm)
small molecules (metabolites) (1 nm)
bilayer membrane (5 nm thick)
average protein (8 nm diameter)
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Document Summary

The cytoplasm is crowded with protein and other macromolecules. Proteins are constantly bumping into other proteins and many of these form semi-stable complexes. There is a limited volume through which small molecules can move. To be able to visualize biochemical reactions, it is necessary to have an understanding of scale. Some important dimension water (0. 3-0. 4 nm) small molecules (metabolites) (1 nm) bilayer membrane (5 nm thick) average protein (8 nm diameter) ribosome (25 nm) 15,000 per e. coli cell green light (550 nm. 1 m in humans mitochondrion (2000 nm long x 400 nm diameter) bacterium (3000 nm long x 600 nm diameter) chloroplast (8000 nm long x 1500 nm diameter) plant cell (50000 nm diameter) Errors: genetic defects that lead to defective proteins with an inability to function normally. Metabolism: the enzyme-catalyzed reactions that interconvert biochemical substances. Almost always associated with the accumulation of compounds in the urine, hence suffix.

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