BCHM 10000 Lecture Notes - Lecture 15: Protein Secondary Structure, Ribonuclease, Pymol
27 Jun 2018
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Slide 1
• Amino acids can be linked together to form peptides and proteins
– a protein is a very long peptide
– a protein may contain 100 to 1000 amino acid residues
• Amino acids are linked together by peptide bonds
– indirectly involves removal of the elements of water
The Peptide Bond
BCHM 100 Weeks 7 - 8
Primary sequence
Glutamine, alanine
Polypeptide-
Lots of peptide bonds
When 2 amino acids join, you
create a peptide bond and you
lose water
Can also have disulfide
bond/bridges in protein
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Slide 2
alanine valine
glutamate
BCHM 100 Weeks 7 - 8
Proteins always begin
at amino group
C
C
C
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Slide 3
• Proteins have 4 levels of structure
–primary
•the linear sequence of amino acids in a protein
– secondary
•the local 3-dimensional structure of the peptide backbone
– tertiary
•the global arrangement of secondary structure, amino acid R groups and
prosthetic groups
– quaternary
•the arrangement of multiple protein molecules in complexes
Protein Structure
BCHM 100 Weeks 7 - 8
Valine
Alanine
Glutamate
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Document Summary
The peptide bond: amino acids can be linked together to form peptides and proteins. A protein is a very long peptide. A protein may contain 100 to 1000 amino acid residues: amino acids are linked together by peptide bonds. Indirectly involves removal of the elements of water. When 2 amino acids join, you create a peptide bond and you lose water. Protein structure: proteins have 4 levels of structure. Primary the linear sequence of amino acids in a protein. Secondary the local 3-dimensional structure of the peptide backbone. Tertiary the global arrangement of secondary structure, amino acid r groups and prosthetic groups. Quaternary the arrangement of multiple protein molecules in complexes. Primary structure: a peptide bond is formed between the carboxyl group of the first amino acid and the amino group of the next . C-terminal (carboxy terminal) amino acid: the atoms of the peptide bonds and the alpha-carbons form the peptide.
