ANSC 23000 Lecture Notes - Lecture 1: Ferrochelatase, Porphyria, Erythropoiesis
12 Dec 2016
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ANSC 230 RBCs
• Hematopoiesis: production of blood cells
o Blood supplies cells with water, electrolytes, nutrients, heat, and
hormones, and removes waste products
• Red Blood Cells (RBCs): erythrocytes(erthro: red cyte: cell) are red blood
cells (pale in middle and thin, biconcave) that carry Oxygen to tissues and
have a finite life span, also anuclear (no nucleus)
o How function: Hemoglobin (carrier protein molecule), a RBC capable
of bringing the hemoglobin to cellular level in tact, and a metabolism
geared to protect the Hemoglobin and RBC from damage
▪ Hemoglobin (heme: iron-containg unit globin: protein)
• Comp: 4 hemes attached to 4 globins (2 alpha 2 beta)
and iron is added at the end by ferrochelatase enzyme
• Interference w/ production of heme or
globin=inbalanced=anemia(copper or iron deficiency or
lead poison)
• Only issue known in animals is porphyria causing severe
photosensitivity in cattle
o Red cell mass and oxygen carrying capacity remain constant in
healthy animals
o Production of red blood cells, erythropoiesis, is regulated by
erythropoietin, a hormone secreted from the kidneys that increases
the prod. rate of RBCs, which increases with hypoxia, deficiency in
amount of oxygen reaching tissues
o Kidney (renal) failure is associated with anemia because it is a major
site of red blood cell production, erythropoiesis
o Erythropoietin acts on marrow with other body fluids, Humoral, to
increase # of stem cells entering RBC production, shorten maturation
time, and cause early release of Reticulocytes, immature RBCs w/o a
nucleus
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