NROSCI 0081 Lecture Notes - Lecture 16: Limbic System, Methamphetamine, Reuptake
Document Summary
Terminology: stimulants: increase cns activity, psychostimulants: drugs that increase brain activity, increase vigilance, alertness, mood. Most increase activity of sympathetic nervous system : sympathomimetics: drugs that activate (or mimic) sympathetic nervous system, stereotypy: involuntary repetitive movements which can be caused by stimulant abuse. History: south americans, 5(cid:1004)(cid:1004)(cid:1004) years, isolated fro(cid:373) (cid:272)o(cid:272)a (cid:271)ush i(cid:374) (cid:1005)85(cid:1004)"s, used as a local anesthetic wine, toothache, medicine, used as medicine (for depression and addiction, harrison narcotics act prohibit non-medical use of cocaine. Medical uses: schedule ii, anesthetic: nasal and lacrimal duct surgery, blocks sodium channels, causes constriction of blood vessels reduce bleeding. Absorption/distribution: lungs to brain in 7 seconds. Quick delivery and high dose to the brain. S(cid:374)orted, i(cid:374)je(cid:272)ted, oral, (cid:272)a(cid:374)"t (cid:271)e s(cid:373)oked (does(cid:374)"t tur(cid:374) to a gas until a high temperature) Injection: less common, same effects as snorting, administration/distribution (15-30s), lasts about 30 mins. Oral: first pass metabolism, absorption distribution (30 mins), less intense high. (function is to take dopamine in synapse and reuptake)
