BIOSC 0350 Lecture 16: Lecture P
16 Dec 2018
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To go from fertilized egg multicellular organism requires: Increase cell number: changes in cell behavior, ex. How do you study development: observation, disrupt physically, ablation, ex. Chopping cluster of cells in half: some species twins or no development, grafting, move tissue. Identify key mechanisms: localize signaling centers/organizers, disrupt genetically. Isolate mutations that cause defects in development: determine function of wt genes, not something easily found via biochem, at least not initially. How is the anterior-posterior axis of limb established: hypothesis: zpa is source of secreted morphogen which specifies different digits above distinct concentrations. Grafting ope chick embryo wing bud leg bud graft posterior piece to anterior limb bud chick wing anterior. A (thumb) (opposite experiment - anterior piece to posterior - does not do this) P (pinky: explanation- anterior zpa is a second morphogen that specifies a new set of t digits.
