BB H 432 Lecture Notes - Lecture 4: Adrenal Gland, Walter Bradford Cannon, Gastrointestinal Tract
Document Summary
Themes: brief history of medicine, key people, models of disease. Clicker question: what happens during the lazarus"s primary appraisal model: the person determines whether a stressor is present in the environment. Fatigue, anxiety without pathology, hysteria, neurosis: 1900s: psychosomatic medicine, mind and body are one, health: psychological and somatic! : physiologist: internal environment must remain constant while external environment changes, current view. Cannon"s homeostasis: the body sends signals to the brain about the state or the organism. How could he study this: bioassay: a measurement of the concentration or potency of a substance by its effect on living cells or tissues. General adaptation syndrome (hans selye (1950-60s): suite of physiological responses, gastrointestinal ulcers (sns, adrenal enlargement (hpa, thymic and lymphatic atrophy (immune, non-specific response: different stressors, same response, timeline of response, alarm: activation, resistance: plateau/maintenance, exhaustion: wear and tear. Models of disease: your model of where disease comes from is an important determinant of which treatments you will select.
