NURS 282 Lecture 6: PathoPharm II Module 6
Document Summary
Integrity: majority stored in bone ~ 98, remainder present in blood, normal: 10mg/dl, 50% bound, 50% free, active, calcium absorption, small intestines ~ 1/3 of ingested calcium. Loss determined by gfr & tubular reabsorption: reduced by pth & vitamin d, reduced w/ thiazides. Intestinal absorption of calcium: ca leaves blood, suppression of pth release, vitamin d activation, calcitonin, released by thyroid gland , works in opposition to pth & vitamin d, renal excretion. Normal a&p cont: vitamin d: forms, ergocalciferol (d2, pharmaceutical products, fortification of food, cholecalciferol (d3, produced naturally from sunlight, available pharmaceutically, physiologic actions, regulates ca, intestinal absorption, resorption in bone, renal excretion of calcium. If serum calcium cannot be maintained through increased intestinal absorption, vitamin d can cause bone decalcification. Lifestyle: walking, yoga, dancing, racquet sports, weight lifting, stair climbing, meds, smoking, excessive etoh or caffeine, gcs, chemo, thyroid replacement levothyroxine, heparin, antacids, comorbidities, cushing"s disease, thyroid dysfunction, hyperparathyroidism, bone tumors, malabsorption dx, anorexia nervosa, underweight, ra.
