NURSE-UN 1435 Lecture Notes - Lecture 3: Lysosome, Cell Membrane, Plasma Cell
8 Oct 2018
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Document Summary
Basophil: produced in bone marrow, circulate in vascular system. Can migrate to connective tissue, but cannot reenter bloodstream. Cytoplasmic granules contain heparin and histamine, mediators of inflammation. Mast cell: produced in bone marrow, found in connective tissue, where they mature; live for weeks to months. Cytoplasmic granules contain histamine and heparin, which enhance immune response. Monocyte: immature macrophages; originate from bone marrow stem cells. Become macrophages when entering tissue and can replenish macrophages and dendritic cells or differentiate into these cells quickly (within 8-12 hrs) when needed during inflammatory response. First immune cells to encounter a pathogen; large, long living phagocytes (can live several months to years). Clean up dead neutrophils and inflammatory debris; secrete cytokines to coordinate activity of other immune cells, which promotes inflammation. General: essential in the process of adaptive humoral immunity. B-cells develop and mature in the bone marrow.
