BIOL-UA 22 Lecture Notes - Lecture 11: Chloroplast Membrane, Signal Peptide, Translocon
18 Mar 2016
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Lecture 11: cell compartments vi: targeting of proteins to mitochondria and. Relatively short (6 to 50 amino acids) Directs a protein to speciic location in the cell zip code. Er located in n-terminus sequence is removed, 6-12 aa. Mitochondrion located in n-terminus sequence is removed, Chloroplast located in n-terminus sequences is removed, no common motifs. Peroxisome c & n-terminus sequence is not removed, pts1 & Nucleus location varies sequence is not removed, multiple different kinds. Bilayer membrane presents challenge for protein transport into the mitochondria. Some proteins are inherent to mitochondria as it has it"s own genome, though some are encoded in the nuclear genome. Slide 9: the mitochondrial genome encodes only fraction of the mitochondrial proteins: ask about this. You need all the machinery to transcribe and translate, some are encoded in the nuclear genome but some are encoded within the mitochondrial genome different than what"s found in the cell. Mitochondria encodes its own rrna, trna, cytochrome c.
