BIOL-UA 21 Lecture Notes - Lecture 17: Cpg Site, Cpg Oligodeoxynucleotide, Tata Box

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copperclam97

18 Mar 2016

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Tethering = forming dna platform for the transcription initiation factors to bind. Downstream control tissue specific and temporal expression. Transcribed at lower late, compose 60% of the promoter gene. May find multiple transcription factors thus don"t control the start site precisely. Divergent transcription = can do transcription in both directions. In vertebrates, cs are methylated at cpg (c next to a g) Due to mutations converting methylated cs there is less cpg sequences than expected. In the sea of cpg deficient genome sequence. ~1000 bp and elevated g/c composition, little cpg depletion, frequently less c methylation. Less precise transcription start sites, more divergent transcription (transcription in both directions from the promoter) Some cpg islands contain tata box and promoter proximal. Eukaryotic basal promoter element consensus sequences sequences, some don"t. Consensus sequence for tata box differs per species but usually contain tata.

Related Questions

1 DNA sequences found in introns provide [A] amino acid sequence information.

[B] regulatory information.
[C] no known useful information.

[D] structure for the gene.
[E] alternative DNA splicing possibilities.

3. The TATA box is a(n)
[A] sequence close to the promoter region of many genes.
[B] square-shaped sequence.
[C] enhancer consensus sequence.
[D] activator sequence necessary for proper translation.
[E] None of the above

5. Regarding genes and gene expression, which of the following is not a difference between prokaryotes and eukaryotes
[A] Eukaryotic DNA does not contain a TATA box close to the initiation site as does prokaryotic DNA.

[B] In eukaryotes, RNA polymerase requires

'transcription factors'or initiation.

[C] Prokaryotic genes are often grouped together in

operons.

[D] In eukaryotes, the regulation of several genes at once requires common control elements in each of the genes.
[E] There is a diversity of eukaryotic polymerases that is reflected in the diversity of eukaryotic promoters.

10) In eukaryotic cells, a repressor

[A] is made of DNA.
[B] binds to the enhancer region to block transcription. [

C] is located both upstream and downstream from the promoter.
[D] binds to the operator to block RNA polymerase.

[E] binds to a silencer to reduce transcription rates.

Coordinated regulation of genes in eukaryotic cells [A] is the result of positioning the same regulatory sequence in front of each gene.
[B] results from all of those genes being under the control of one promoter.

[C] occurs because related genes all have the same

operons.
[D] occurs because enhancers cause DNA to bend.

BIOL-UA 21 Lecture Notes - Lecture 17: Cpg Site, Cpg Oligodeoxynucleotide, Tata Box

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