BIOL 2299 Lecture Notes - Lecture 4: Asymmetric Cell Division, Ecological Niche, Cadherin
16 Mar 2016
School
Department
Course
Professor
Document Summary
Pj darlington"s (1972) concept of niche compared to raymond schofield"s (1978: comparing cellular niche to environmental niche. Niche: function: support stem cell function, fate, proliferation, asymmetric division, niche components are variable. Niche in intestine is very different from niche in bone marrow: however, all have: Physically anchor cells via integrins and cadherins. Secrete signals to regulate stem cell division (notch, wnt, shh, bmp, When taken out niche, stem cells are tricky to grow. When you take cells from around stem cell and grow stem cells with those cells, easier to grow. Hypoxia is a prominent feature in most. Different concentration of oxygen in different niches. Deregulation of niche: niche can be the source of abhorrent signaling. Cells then do not know what to do. Could be the niche that is causing the cancer, incorrect signaling. Expansion of niche, permits expansion of cancer stem cells.
