BIOL 1107 Lecture Notes - Lecture 10: Cell Adhesion Molecule, Cadherin, Integrin
6 Nov 2016
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Cell junctions: each have different structure and function. Anchoring junctions: anchors cell to components of the ecm, keeps cell in specific position within tissue. Tight junctions: hold two cells very close to prevent substance leakage through membrane. Gap junctions: allows connections between cytoplasm for small molecule movement. Attach cells to each other and to ecm. Rely on cell adhesion molecules bound to cytoskeleton. Cadherin: create cell-to-cell junctions: ca+ dependence, extracellular domain bound to other cadherin, intracellular domain to cytoskeleton. Integrin: binds cell to ecm: extracellular domain bound to other ecm, intracellular domain to cytoskeleton. Bind to each to form tight seal. Not mechanically strong, not bound to cytoskeleton: keeps substances in to be digested. Small gap between plasma membrane of cells at junction. Six connexin proteins in one cell align with six connexin proteins in an adjacent cell to form a connexon connexon allows passage of ions and small molecules.
