BIOL 1107 Lecture Notes - Lecture 2: Phosphodiester Bond, Deoxyribose, Ribose

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Dna is a nucleic acid composed of nucleotides: nitrogenous base (base not acid) Purine (a,g) and pyrimidines (c,t,u: pentose sugar (i. e. c5h1005, phosphate group (-3 charge, deoxyribose has h and oh, ribose has oh and oh. Nucleotides are linked by a phosphodiester bond between the phosphate group at the c-5" position and the oh group on the c- 3" position: polynucleotides chains consisting of 20+ nucleotides, phosphate is on the 5" carbon. 5" phosphate group: 5" carbon attached to phosphate group. 3" hydroxyl group (oh): open/not attached to anything. Chromosome= dna + associated protein hundreds of thousands genes on each chromosome (1 linear structure), code for polypeptides. Transcription occurs in nucleus of eukaryotes: ribosomes in cytoplasm, Rna chemically modified in nucleus in eukaryotes vs. prokaryotes where it is immediately available for translation. Rna used for protein synthesis = mrna. All cells have the same dna, gene expression makes cells perform different functions. Mediator mediates interactions of activator and depressors.

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