BIOL 411 Lecture Notes - Lecture 3: Hydrogen Bond, Protein Folding, Chemical Polarity

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11 Jan 2017
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Bio411.01
2/3/16
Atom: protons, neutrons (nucleus), and electrons
Electrons shells
o First shell- maximum 2 electrons (1s orbital)
o Second shell- maximum 8 electrons (2s and 2p orbitals)
Coalet od: 2 atos shae a eleto pai i a oleula oital alee
electrons)
Polar bond: between two atoms of different electronegativity
o Water has 2 polar bonds, O is an electron hog (high electronegativity value [E])
Hydrogen bond: association of a hydrogen atom (w/ partial positive charge) and an
electronegative atom (w/ a partial negative charge)
o Only H bonded with O, N, or F will form a hydrogen bond
o Water molecules stick together with hydrogen bonds, hydrogen bonds with
oxygen
o Guanine and Cytosine are bonded together by hydrogen bonds in DNA and RNA
Allows DNA and RNA to replicate
Water is a polar molecule
o Polar molecules are hydrophilic- likes water
o Nonpolar molecules are hydrophobic- does’t like ate
o There are aqueous and nonaqueous phases
Membranes are nonpolar, hydrophobic environment- helps mask/shield themselves
from water
Proteins are made of long chains of amino acids, as amino acids are added the protein is
folding (instructions for folding usually given by the amino acids), one of the major
dies of potei foldig is a egio of nonpolar amino acids that fold down because
they want to escape water
o hydophoi effet
Aids: poto doo, aids ill elease potos H+ ito the aueous solutio, oe
H+ in the solution
o Low pH
Bases: accepts protons, so there are fewer H+ ions in the solution
o High pH
pH: the measure of the proton content (hydrogen ion concentration) of a solution
expressed as the negative log of the hydrogen ion concentration
o Ex: 10-4 ions, log10-4= -4 (negative)= 4
Carbon:
o Carbon based life form
o 4 valence electrons, so 4 covalent bonds
o 6 electrons total
o Forms 4sp3 hybrid orbitals so the electrons can be as far away as possible from
eachother
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