BMCB 658 Lecture Notes - Lecture 22: Hydration Reaction, Gluconeogenesis, Vitamin B12 Deficiency
19 Aug 2016
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Cells that make a lot of steroids also store lipids. Oxidation of fatty acids is the main source of energy. Low blood sugar causes hormones to be secreted (epinephrine and glucagon) Hormone binding activates adenylate cyclase (conformational change of receptor) Dag lipase cleaves 2nd fatty acid (diacylglycerol) Mag lipase cleaves last fatty acid (monoacylglycerol) End up with three free fas and one glycerol in cytosol. Acetyl-coa is fed into tcac and electron transport chain. Energy used to phosphorylate adp to atp. Release of peptide yy (hormone that increases the sensation of satiety, slows. Thioester bond formed between carboxyl group of fatty acid and thiol group of coenzyme a. Equivalent of 2 atps consumed ppi gets cleaved immediately. Acyl-coa can cross outer membrane, but not the inner mitochondrial membrane. In the intermembrane space, acyl transferred to carnitine. Enzyme: carnitine acyltransferase: double bond b/w alpha and beta carbons in trans configuration, electron acceptor: fad.
