GN 311 Lecture Notes - Lecture 17: Chromosome Abnormality, Metastasis, Malignancy
Document Summary
Ability to metastasize spread to other locations. Mass of tissue that can grow in an unregulated way and has no real purpose. Typically, there is a mistake/mutation in a single cell and then exacerbates into tumor formation. Cancer is rarely heritable, but is due to changes in dna. Most cancers are sporadic and not handed down generations there are checkpoints within the cell cycle. Abnormal cells remain localized and do not invade surrounding tissue. Cells have invaded other tissues but also establish secondary tumors in other. Most of the time, there are multiple genes that form the cancer (polygenic) Most cancers are sporadic and influenced by environment: Therefore it is (cid:272)o(cid:373)(cid:373)o(cid:374) that populatio(cid:374)s that (cid:373)igrate to (cid:374)ew regio(cid:374)s te(cid:374)d to get cancer rates typical of that region. High incidents of cancer correlate with tissues that undergo more cell divisions . Every time you replicate dna, the dna polymerase makes mistakes.
