BS 182H Lecture Notes - Lecture 17: Craig Mello, Innate Immune System, Antigen-Presenting Cell
17 Mar 2016
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Document Summary
Very cooperative coalition; a body: most cells in body don"t reproduce across generations; they increase copies of shared genes in their close kin"; the gametes, *immune system stabilizes this cooperative coalition by making sure that everyone is on the same team, recognize and defend self, even jellyfish and sponges have some immunity. Innate immunity = recognizing traits shared by a broad range of pathogens (ex: peptidoglycan: small number of receptors, adaptive immunity = recognition of traits specific to particular pathogens, large number of receptors, leukocytes (white blood cells, basophils (and mast cells) release histamines, prostaglandins, cytokines, and pyrogens, eosinophils and natural killer cells (bombs) All organisms have innate" mechanisms: even bacteria, ex: restriction enzymes; chop up dna/rna that"s not supposed to be there, plants and animals have lectins, many glycoproteins that bind sugars on cell surfaces of others", antibodies and complement = vertebrate analogs to lectins.
