MEDT 315 Lecture Notes - Lecture 9: Acute-Phase Protein, Menkes Disease, Globulin
14 Nov 2019
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α2-Globulins
Ceruloplasmin
Synthesized by the liver
Contains copper
Responsible for the activation of iron from Fe3+ to Fe2+
Done through an exchange of electrons between copper and iron
Acute phase reactant
Elevated with severe infection, inflammation, tissue damage, some cancers,
pregnancy, estrogen containing BC, and some medications
Low levels associated with malnutrition, malabsorption (Menkes disease), liver and
kidney diseases
Used to help diagnose Wilson’s disease
Causes a build up of copper in the liver, brain and other organs
α2-Globulins
α2-Macroglobulin
Primary component of the α2-band in electrophoresis
Synthesized by the liver
Tetramer of 4 identical subunits
Inhibits proteases
Trypsin, plasmin, thrombin and kallikrein
Binds to proteases and reduces accessibility to the functional site, but does not
completely inactivate them
Elevated levels seen with kidney disease (10x higher), liver disease, pregnancy, diabetes
and BC use
β-Globulins
Transferrin (Siderophilin)
Synthesized by the liver
Major component of the β-globulin band
Negative acute phase protein
Decreased with inflammation
