MARKET 1 Lecture Notes - Lecture 20: Hormesis, Taylor & Francis, Crc Press
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Just a another set of notes for principles of toxicology 1 they were two lectures but i did them at the same time. Often in toxicology it is the response of a population of organisms to the toxicant that is of interest. In these cases it is usual to study the relationship between increasing exposure to the toxicant and the proportion of the population that exhibits a particular toxicity. Such responses are called quantal or all-or-none response; that is they have only two outcomes. Examples of this type of response include: the proportion of the population that does or does not exhibit liver damage (hepatotoxicity) after exposure; the presence or absence of tumours and whether the organisms are dead or alive. As you might expect, as the level of exposure increases the proportion of the population that shows toxicity also increases until all the population responds. The relationship between the two, however, is not linear.