ELECTRN 8 Lecture Notes - Lecture 3: Muscarine, Ligand-Gated Ion Channel, Second Messenger System
Document Summary
Drugs alter the function of cells and interfere with the chemical transmission across synapses in cns at any stage: synthesis, storage, reuptake, deactivation etc. Agonists: drugs that increase the post-synaptic effect of nt. Antagonists: drugs that decrease the post-synaptic effect of nt. Direct antagonist drug blocks nt receptor. Some receptors have different bonding sites (normally available to neuromodulators) and different ligands (any molecule that binds to another) can attach to it. Drugs can attach here and indirectly affect the function of nt. Indirect agonist may allow the channel to stay open for linger. Indirect antagonist may restrict the channel from opening. Many chemicals that have nt function also have modulatory effects on large areas of the brain. Drugs tend to affect nm and therefore have wide-ranging effects. Peptides: glutamate, gaba, ach, dopamine (da, seratonin (5ht, noradrenalin (na, enkephalins, substance p, oxytocin.
