DANCEST 805 Lecture Notes - Lecture 3: Carbamino, Electrochemical Gradient, Carbonic Anhydrase
Document Summary
6o2 + c6h12o6 6co2 + 6h2o: 0. 16g h2o/min, 1. 22 kcal heat/min, 200ml co2/min lots. 40ml co2/l of blood would impact ph so excreted by lungs. How is co2 carried: physically dissolved exerts partial pressure, bound to proteins as carb-amino compounds in plasma/rbcs i. e. nhcoo- & hb, as hco3. Diffuses out of tissues into plasma due to partial pressures. O2 moves along its partial pressure gradient deoxyhb. Inc in rbc moves down conc gradient into plasma. Rebalanced by influx of cl- - chloride shift. Ve charge of carb-amino compound neutralises h+ - balances ph. Hb in rbcs can also buffer h+ - forms carb-amino compounds. If h+ wasn"t buffered co2 would reach eqbm. Co2 content on y, pco2 on x-axis. *note: cannot use co2 saturation majority of co2 as hco3. At paco2 (5kpa) hbo2 97. 5% saturated & 480ml co2/l of blood. Not a waste" product significant amounts in arterial blood.
