DANCEST 805 Lecture Notes - Lecture 20: Immunoglobulin Superfamily, Helminths, Addressin
Document Summary
Learning outcomes: be introduced to chemokines and their receptors, know the different steps in leukocyte extravasation, understand roles of chemokines and adhesion molecules in extravasation, appreciate the major chemokine-receptor pathways in homeostasis and inflammation. Immune cells constantly circulate/patrol via the blood and lymph. They get to the right place using chemokines and adhesion molecules. Once bound to the target cell as chemokine concentration increases there will be cytoskeletal rearrangement. Many chemokines bind multiple receptors and many receptors bind multiple chemokines. Chemokines are produced by immune cells and also non-immune cells. Leukocytes: t cells (cd4 and cd8) only from thymus, other cells are bone marrow, b cells, monocytes, neutrophils, travel from spleen, bone marrow and thymus to lymph nodes. Lymph carried signals from peripheral tissues to draining lymph nodes. Hev: high endothelial venule, have thick layer of endothelial cells with surface glycoproteins called addressins. Blood moves out of lymph node via this.
