BIOLOGY 25 Lecture Notes - Lecture 15: Trismus, Dysautonomia, Monoamine Transporter
Document Summary
Problem 2 after every party i die. Learning goals: how does cocaine work? (chapter 10) Cocaine powder & crack have identical dynamic effects difference in kinetics (crack can be smoked) All harms caused by cocaine don"t occur when released very slowly into brain (by chewing) Not necessarily a drug itself is source of harm, but the route of use & the drug"s social context. Working mechanism: blocks dopamine transporter/reuptake in brain increase in dopamine. Often treated with ritalin is a dopamine reuptake inhibitor: blocks dopamine transporters similar to cocaine. Ereader: ritalin = methylphenidate; used to treat adhd: Weak dopamine signals interesting activities provide viewer rewards. Attention circuity is underfed: random distracting neuron firing interferes with concentration more distractible. Ritalin uppers signal, reduces noise: pills taken orally rarely produce a high; not addictive, different addiction potential due to speed of dopamine increase (ritalin: 1 h cocaine: few seconds)
