BIOL-N - Biology BIOL-N 217 Lecture Notes - Lecture 6: Eicosanoid, Calcium Channel Blocker, Endocytosis
13 Sep 2017
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Within a cell (axon of a neuron) Secretion of chemicals into extracellular fluid (ecf) What a cell is supposed to become. Enters blood stream, travels through blood, if there is a receptor there is a response. Telling cells what they are supposed to be. Kinase may be intrinsic part of the receptor protein. Jak kinase (janus family tyrosine kinase) - a separate cytosol kinase activated by the receptor. G protein 1 of 2 functions. Alter enzyme function in the cytosol alter an amplifier protein. Adenylyl cyclase amplifier enzyme: atp (cid:314) camp. G protein-coupled receptors & lipid 2nd messengers. Phospholipase c amplifier enzyme: diacylglycerol (dag) & inositol triphosphate (ip3) Dag in membrane activates protein kinase c (pkc) Ip3 in cytosol - opens ca2+ channels in er, ca2+ acts as a signal. Alters cell membrane potential allows ion movement. Ach receptor ligand or chemical gated channel. Cation channel allows na+ and k+ to move.
