Chemistry CHEM S-20ab Lecture Notes - Lecture 29: Organic Chemistry, Methylmalonyl-Coa, Erythromycin
30 Apr 2018
School
Department
Course
Professor
!""#$%$ &'(')*$+,$-.+/$$
Fa#y%Acid*Biosynthesis:*
+0$121$3456$7489:;45$
+<=$
>?"$fa#y%acids$:8"$@45(2A?:B5$A:8C4DE@BA$:AB6),$@B#"$F:@9B;A$:AB6$G:$):*'8:*"6$H:IE$:AB6$
H4'56$B5$F:@9$4B@,$:945($4*?"8$H446)0J$
7:IE$:AB6)$:8"$also%)E5*?")BK"6$H849$:A"*E@$14&L$$>?"$first*steps*B5$H:IE2:AB6$)E5*?")B)$
B5M4@M"$*?"$forma8on*of*a*carbon%carbon*bondL$$N84F4)"$:$9"A?:5B)9J$
OH
O
palmitic(acid
SCoA
O
OSCoA
OO
O S
OO
ACP
S
OO
ACP
S
O
KS
SCoA
O
+
KS'='KetoSynthase
CO2
HS ACP
ACP&=' Acyl'Carrier'Protein
acetoacetyl&ACP
ReadingJ$O"A;45$--L%$
!""#$%$ &'(')*$+,$-.+/$$
Fa#y%Acid*Biosynthesis:*
-0$1?:5(B5($7'5A;45:@$P84'F)$
+<Q$
R4S$*?:*$*?"$5"S$121$C456$?:)$C""5$H489"6,$S"$9')*$8"6'A"$*?"$#"*45"$*4$*?"$:@#:5"$
A?:B5$S"$6")B8"L$$N84F4)"$9"A?:5B)9)$H48$*?"$H4@@4SB5($)*"F)T$54*"$*?:*$)49"$cofactors$$
SB@@$C"$8"U'B8"6J$
>?"$S?4@"$F84A"))$:66"6$-$A:8C45)$*4$:A"*E@$14&L$$>?"$F84A"))$A:5$C"$8"F":*"6J$
S
OO
ACP
S
OOH
ACP
S
O
ACP
S
O
ACP
KetoReductase
(KR)
DeHydratase
(DH)
Enoyl2Reductase
(ER)
S
O
ACP
SCoA
O
S
O
ACP
Ac'CoA Ac'CoA Ac'CoA
etc.
