HONR 1034 Lecture Notes - Lecture 2: Neutropenia, Haematopoiesis, Leukemia
Document Summary
B. different disorders originate from lymphoid or myeloid precursors. 3. results of accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues. D. time frame of days to weeks for signs and symptoms; acute leukemia presents with features of bone marrow failure (anemia, infections, easy bruising, or hemorrhage) A. malignancy of a committed myeloid progenitor cell (don"t go past a certain step in. C. aml is a proliferation of abnormal blasts that fail to differentiate properly and they. Iii. origins of aml (acute myeloid leukemia) evolving so fail to acquire important survival assets; like don"t make rbcs) proliferate without maturing immature cells causing them to pour out into the bloodstream/lymph. D. risk factors; exposure to benzene (everyday chemical that causes blood cancer) E. result is anemia, neutropenia, and thrombocytopenia: overproduction of defective, 1. fatigue, malaise, profound weakness worsening about 2-3 months which is bone marrow failure.
