HONR 1033 Lecture Notes - Lecture 8: Natural Killer Cell, B Cell, Vacuole
Document Summary
A. innate immunity using a set of receptors, rapid response. 1. all animals; bacteria, fungus, virus (pathogens) being recognized by the cell. Internal defenses: phagocytic cells,natural killer cells, antimicrobial proteins, inflammatory response. B. adaptive immunity; pathogens using a vast array of receptors, slower response. 2. humoral response: antibodies defend against infection in body fluids. Cytotoxic cells defend against infection in body cells. 3. neutrophils digest pathogens and cell debris. tissue heals. A. antigen-any substance that elicits a b or t cell response. B. antigen receptor-binds t onoe part of one molecule of particular pathogen. 1. cell of the immune response-millions of different antigen receptors. 2. but, a given lymphocyte only has one variety. C. epitope-small, accessible portion of an antigen that binds to the antigen receptor. A. constant (c) region- aa sequences vary little among receptors on different b cells. D. antibody- secreted soluble form of the receptor; direct defense against pathogens in. A. variable and constant regions responsible for antigen-binding to the receptor.
